10% Humano
Bibliografia
A literatura científica sobre o papel da microbiota na saúde física e mental do ser
humano vem crescendo com impressionante rapidez. Trata-se de um campo
novo, que se estabeleceu há cerca de uma década. Além de muitas conversas
pessoais, telefônicas e por e-mail com alguns dos maiores cientistas
especializados no assunto, grande parte das pesquisas que serviram de base para
este livro vem de fontes primárias – publicações em periódicos científicos em
língua inglesa. As informações contidas neste livro vêm de centenas de artigos –
mais do que seria possível listar aqui. Incluo, portanto, apenas uma pequena
bibliografia com referências aos estudos mais importantes e interessantes
abordados em 10% humano e algumas sugestões de leituras.
Introdução
1. International Human Genome Sequencing Consortium (2004). Finishing the euchromatic sequence
of the human genome. Nature 431: 931-945.
2. Nyholm, S. V. e McFall-Ngai, M. J. (2004). The winnowing: Establishing the squid-Vibrio symbiosis.
Nature Reviews Microbiology 2: 632-642.
3. Bollinger, R. R. et al. (2007). Biofilms in the large bowel suggest an apparent function of the human
vermiform appendix. Journal of Theoretical Biology 249: 826-831.
4. Short, A. R. (1947). The causation of appendicitis. British Journal of Surgery 53: 221-223.
5. Barker, D. J. P. (1985). Acute appendicitis and dietary fibre: an alternative hypothesis. British Medical
Journal 290: 1125-1127.
6. Barker, D. J. P. et al. (1988). Acute appendicitis and bathrooms in three samples of British children.
British Medical Journal 296: 956-958.
7. Janszky, I. et al. (2011). Childhood appendectomy, tonsillectomy, and risk for premature acute
myocardial infarction – a nationwide population-based cohort study. European Heart Journal 32: 2290-2296.
8. Sanders, N. L. et al. (2013). Appendectomy and Clostridium difficile colitis: Relationships revealed by
clinical observations and immunology. World Journal of Gastroenterology 19: 5607-5614.
9. Bry, L. et al. (1996). A model of host-microbial interactions in an open mammalian ecosystem.
Science 273: 1380-1383.
10. The Human Microbiome Project Consortium (2012). Structure, function and diversity of the healthy
human microbiome. Nature 486: 207-214.
Capítulo 1
1. Gale, E.A.M. (2002). The rise of childhood type 1 diabetes in the 20th century. Diabetes 51: 3353-
3361.
2. Organização Mundial da Saúde (2014). Global Health Observatory Data – Overweight and Obesity.
Disponível em: http://www.who.int/gho/ncd/risk_factors/overweight/en/.
3. Centers for Disease Control and Prevention (2014). Prevalence of Autism Spectrum Disorder Among
Children Aged 8 Years – Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2010. o MMWR 63 (N SS-02): 1-21.
4. Bengmark, S. (2013). Gut microbiota, immune development and function. Pharmacological Research
69: 87-113.
5. von Mutius, E. et al. (1994) Prevalence of asthma and atopy in two areas of West and East Germany.
American Journal of Respiratory and Critical Care Medicine 149: 358-364.
6. Aligne, C.A. et al. (2000). Risk factors for pediatric asthma: Contributions of poverty, race, and urban
residence. American Journal of Respiratory and Critical Care Medicine 162: 873-877.
7. Ngo, S. T., Steyn, F. J. e McCombe, P. A. (2014). Gender differences in autoimmune disease. Frontiers
in Neuroendocrinology 35: 347-369.
8. Krolewski, A. S. et al. (1987). Epidemiologic approach to the etiology of type 1 diabetes mellitus and
its complications. The New England Journal of Medicine 26: 1390-1398.
9. Bach, J.-F. (2002). The effect of infections on susceptibility to autoimmune and allergic diseases. The
New England Journal of Medicine 347: 911-920.
10. Uramoto, K.M. et al. (1999) Trends in the incidence and mortality of systemic lupus erythematosus,
1950-1992. Arthritis & Rheumatism 42: 46-50.
11. Alonso, A. e Hernan, M. A. (2008). Temporal trends in the incidence of multiple sclerosis: A
systematic review. Neurology 71: 129-135.
12. Werner, S. et al. (2002). The incidence of atopic dermatitis in school entrants is associated with
individual lifestyle factors but not with local environmental factors in Hannover, Germany. British Journal of Dermatology 147: 95-104.
Capítulo 2
1. Bairlein, F. (2002). How to get fat: nutritional mechanisms of seasonal fat accumulation in migratory
songbirds. Naturwissenschaften 89: 1-10.
2. Heini, A. F. e Weinsier, R. L. (1997). Divergent trends in obesity and fat intake patterns: The
American paradox. American Journal of Medicine 102: 259-264.
3. Silventoinen, K. et al. (2004). Trends in obesity and energy supply in the WHO MONICA Project.
International Journal of Obesity 28: 710-718.
4. Troiano, R. P. et al. (2000). Energy and fat intakes of children and adolescents in the United States:
data from the National Health and Nutrition Examination Surveys. American Journal of Clinical Nutrition 72: 1343s-1353s.
5. Prentice, A. M. e Jebb, S. A. (1995). Obesity in Britain: Gluttony or sloth? British Journal of Medicine
311: 437-439.
6. Westerterp, K. R. e Speakman, J. R. (2008). Physical activity energy expenditure has not declined
since the 1980s and matches energy expenditures of wild mammals. International Journal of Obesity 32: 1256-1263.
7. Organização Mundial da Saúde (2014). Global Health Observatory Data – Overweight and Obesity.
Disponível em: http://www.who.int/gho/ncd/risk_factors/overweight/en/.
8. Speliotes, E. K. et al. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated
with body mass index. Nature Genetics 42: 937-948.
9. Marshall, J. K. et al. (2010). Eight year prognosis of postinfectious irritable bowel syndrome following
waterborne bacterial dysentery. Gut 59: 605-611.
10. Gwee, K.-A. (2005). Irritable bowel syndrome in developing countries – a disorder of civilization or
colonization? Neurogastroenterology and Motility 17: 317-324.
11. Collins, S. M. (2014). A role for the gut microbiota in IBS. Nature Reviews Gastroenterology and
Hepatology 11: 497-505.
12. Jeffery, I. B. et al. (2012). An irritable bowel syndrome subtype defined by species-specific alterations
in faecal microbiota. Gut 61: 997-1006.
13. Bäckhed, F. et al. (2004). The gut microbiota as an environmental factor that regulates fat storage.
Proceedings of the National Academy of Sciences 101: 15718-15723.
14. Ley, R. E. et al. (2005). Obesity alters gut microbial ecology. Proceedings of the National Academy of
Sciences 102: 11070-11075.
15. Turnbaugh, P. J. et al. (2006). An obesity-associated gut microbiome with increased capacity for
energy harvest. Nature 444: 1027-1031.
16. Centers for Disease Control (2014). Obesity Prevalence Maps. Disponível em:
http://www.cdc.gov/obesity/data/lirevalence-maps.html.
17. Gallos, L. K. et al. (2012). Collective behavior in the spatial spreading of obesity. Scientific Reports 2:
no 454.
18. Christakis, N. A. e Fowler, J. H. (2007). The spread of obesity in a large social network over 32 years.
The New England Journal of Medicine 357: 370-379.
19. Dhurandhar, N. V. et al. (1997). Association of adenovirus infection with human obesity. Obesity
Research 5: 464-469.
20. Atkinson, R. L. et al. (2005). Human adenovirus-36 is associated with increased body weight and
paradoxical reduction of serum lipids. International Journal of Obesity 29: 281-286.
21. Everard, A. et al. (2013). Cross-talk between Akkermansia muciniphila and intestinal epithelium
controls diet-induced obesity. Proceedings of the National Academy of Sciences 110: 9066-9071.
22. Liou, A. P. et al. (2013). Conserved shifts in the gut microbiota due to gastric bypass reduce host
weight and adiposity. Science Translational Medicine 5: 1-11.
Capítulo 3
1. Sessions, S. K. e Ruth, S. B. (1990). Explanation for naturally occurring supernumerary limbs in
amphibians. Journal of Experimental Biology 254: 38-47.
2. Andersen, S. B. et al. (2009). The life of a dead ant: The expression of an adaptive extended
phenotype. The American Naturalist 174: 424-433.
3. Herrera, C. et al. (2001). Maladie de Whipple: Tableau psychiatrique inaugural. Revue Médicale de
Liège 56: 676-680.
4. Kanner, L. (1943). Autistic disturbances of affective contact. Nervous Child 2: 217-250.
5. Centers for Disease Control and Prevention (2014). Prevalence of Autism Spectrum Disorder Among
Children Aged 8 Years – Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2010. o MMWR 63 (N SS-02): 1-21.
6. Bolte, E. R. (1998). Autism and Clostridium tetani. Medical Hypotheses 51: 133-144.
7. Sandler, R. H. et al. (2000). Short-term benefit from oral vancomycin treatment of regressive-onset
autism. Journal of Child Neurology 15: 429-435.
8. Sudo, N., Chida, Y. et al. (2004). Postnatal microbial colonization programs the hypothalamic-
pituitary-adrenal system for stress response in mice. Journal of Physiology 558: 263-275.
9. Finegold, S. M. et al. (2002). Gastrointestinal microflora studies in late onset autism. Clinical
Infectious Diseases 35 (Suplemento 1): S6-S16.
10. Flegr, J. (2007). Effects of Toxoplasma on human behavior. Schizophrenia Bulletin 33: 757-760.
11. Torrey, E. F. e Yolken, R. H. (2003). Toxoplasma gondii and schizophrenia. Emerging Infectious
Diseases 9: 1375-1380.
12. Brynska, A., Tomaszewicz-Libudzic, E. e Wolanczyk, T. (2001). Obsessive-compulsive disorder and
acquired toxoplasmosis in two children. European Child and Adolescent Psychiatry 10: 200-204.
13. Cryan, J. F. e Dinan, T. G. (2012). Mind-altering microorganisms: the impact of the gut microbiota
on brain and behaviour. Nature Reviews Neuroscience 13: 701-712.
14. Bercik, P. et al. (2011). The intestinal microbiota affect central levels of brain-derived neurotropic
factor and behavior in mice. Gastroenterology 141: 599-609.
15. Voigt, C. C., Caspers, B. e Speck, S. (2005). Bats, bacteria and bat smell: Sex-specific diversity of
microbes in a sexually-selected scent organ. Journal of Mammalogy 86: 745-749.
16. Sharon, G. et al. (2010). Commensal bacteria play a role in mating preference of Drosophila
melanogaster. Proceedings of the National Academy of Sciences 107: 20051-20056.
17. Wedekind, C. et al. (1995). MHC-dependent mate preferences in humans. Proceedings of the Royal
Society B 260: 245-249.
18. Montiel-Castro, A. J. et al. (2013). The microbiota-gut-brain axis: neurobehavioral correlates, health
and sociality. Frontiers in Integrative Neuroscience 7: 1-16.
19. Dinan, T. G. e Cryan, J. F. (2013). Melancholic microbes: a link between gut microbiota and
depression? Neurogastroenterology & Motility 25: 713-719.
20. Khansari, P. S. e Sperlagh, B. (2012). Inflammation in neurological and psychiatric diseases.
Inflammopharmacology 20: 103-107.
21. Hornig, M. (2013). The role of microbes and autoimmunity in the pathogenesis of neuropsychiatric
illness. Current Opinion in Rheumatology 25: 488- 495.
22. MacFabe, D. F. et al. (2007). Neurobiological effects of intraventricular propionic acid in rats:
Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders. Behavioural Brain Research 176: 149-169.
Capítulo 4
1. Strachan, D. P. (1989). Hay fever, hygiene, and household size. British Medical Journal, 299: 1259-
1260.
2. Rook, G. A. W. (2010). 99th Dahlem Conference on Infection, Inflammation and Chronic
Inflammatory Disorders: Darwinian medicine and the ‘hygiene’ or ‘old friends’ hypothesis. Clinical & Experimental Immunology 160: 70-79.
3. Zilber-Rosenberg, I. e Rosenberg, E. (2008). Role of microorganisms in the evolution of animals and
plants: the hologenome theory of evolution. FEMS Microbiology Reviews 32: 723-735.
4. Williamson, A. P. et al. (1977). A special report: Four-year study of a boy with combined immune
deficiency maintained in strict reverse isolation from birth. Pediatric Research 11: 63-64.
5. Sprinz, H. et al. (1961). The response of the germ-free guinea pig to oral bacterial challenge with
Escherichia coli and Shigella flexneri. American Journal of Pathology 39: 681-695.
6. Wold, A. E. (1998). The hygiene hypothesis revised: is the rising frequency of allergy due to changes
in the intestinal flora? Allergy 53 (s46): 20-25.
7. Sakaguchi, S. et al. (2008). Regulatory T cells and immune tolerance. Cell 133: 775-787.
8. Östman, S. et al. (2006). Impaired regulatory T cell function in germfree mice. European Journal of
Immunology 36: 2336-2346.
9. Mazmanian, S. K. e Kasper, D. L. (2006). The love-hate relationship between bacterial
polysaccharides and the host immune system. Nature Reviews Immunology 6: 849-858.
10. Miller, M. B. et al. (2002). Parallel quorum sensing systems converge to regulate virulence in Vibrio
cholerae. Cell 110: 303-314.
11. Fasano, A. (2011). Zonulin and its regulation of intestinal barrier function: The biological door to
inflammation, autoimmunity, and cancer. Physiological Review 91: 151-175.
12. Fasano, A. et al. (2000). Zonulin, a newly discovered modulator of intestinal permeability, and its
expression in coeliac disease. The Lancet, 355: 1518-1519.
13. Maes, M., Kubera, M. e Leunis, J.-C. (2008). The gut-brain barrier in major depression: Intestinal
mucosal dysfunction with an increased translocation of LPS from gram negative enterobacteria (leaky gut) plays a role in the inflammatory pathophysiology of depression. Neuroendocrinology Letters 29: 117-124.
14. de Magistris, L. et al. (2010). Alterations of the intestinal barrier in patients with autism spectrum
disorders and in their first-degree relatives. Journal of Pediatric Gastroenterology and Nutrition 51: 418-424.
15. Grice, E. A. e Segre, J. A. (2011). The skin microbiome. Nature Reviews Microbiology 9: 244-253.
16. Farrar, M. D. e Ingham, E. (2004). Acne: Inflammation. Clinics in Dermatology 22: 380-384.
17. Kucharzik, T. et al. (2006). Recent understanding of IBD pathogenesis: Implications for future
therapies. Inflammatory Bowel Diseases 12: 1068-1083.
18. Schwabe, R. F. e Jobin, C. (2013). The microbiome and cancer. Nature Reviews Cancer 13: 800-812.
Capítulo 5
1. Nicholson, J. K., Holmes, E. & Wilson, I. D. (2005). Gut microorganisms, mammalian metabolism
and personalized health care. Nature Reviews Microbiology 3: 431-438.
2. Sharland, M. (2007). The use of antibacterials in children: a report of the Specialist Advisory
Committee on Antimicrobial Resistance (SACAR) Paediatric Subgroup. Journal of Antimicrobial Chemotherapy 60 (S1): i15-i26.
3. Gonzales, R. et al. (2001). Excessive antibiotic use for acute respiratory infections in the United States.
Clinical Infectious Diseases 33: 757-762.
4. Dethlefsen, L. et al. (2008). The pervasive effects of an antibiotic on the human gut microbiota, as
revealed by deep 16S rRNA sequencing. PLoS Biology 6: e280.
5. Haight, T. H. e Pierce, W. E. (1955). Effect of prolonged antibiotic administration on the weight of
healthy young males. Journal of Nutrition 10: 151-161.
6. Million, M. et al. (2013). Lactobacillus reuteri and Escherichia coli in the human gut microbiota may
predict weight gain associated with vancomycin treatment. Nutrition & Diabetes 3: e87.
7. Ajslev, T. A. et al. (2011). Childhood overweight after establishment of the gut microbiota: the role of
delivery mode, pre-pregnancy weight and early administration of antibiotics. International Journal of Obesity 35: 522-9.
8. Cho, I. et al. (2012). Antibiotics in early life alter the murine colonic microbiome and adiposity.
Nature 488: 621-626.
9. Cox, L. M. et al. (2014). Altering the intestinal microbiota during a critical developmental window
has lasting metabolic consequences. Cell 158: 705-721.
10. Hu, X., Zhou, Q. e Luo, Y. (2010). Occurrence and source analysis of typical veterinary antibiotics in
manure, soil, vegetables and groundwater from organic vegetables bases, northern China. Environmental Pollution 158: 2992-2998.
11. Niehus, R. M. A. e Lord, C. (2006). Early medical history of children with autistic spectrum disorders.
Journal of Developmental and Behavioral Pediatrics 27 (S2): S120-S127.
12. Margolis, D. J., Hoffstad, O. e Biker, W. (2007). Association or lack of association between
tetracycline class antibiotics used for acne vulgaris and lupus erythematosus. British Journal of Dermatology 157: 540-546.
13. Tan, L. et al. (2002). Use of antimicrobial agents in consumer products. Archives of Dermatology 138:
1082-1086.
14. Aiello, A. E. et al. (2008). Effect of hand hygiene on infectious disease risk in the community setting:
A meta-analysis. American Journal of Public Health 98: 1372-1381.
15. Bertelsen, R. J. et al. (2013). Triclosan exposure and allergic sensitization in Norwegian children.
Allergy 68: 84-91.
16. Syed, A. K. et al. (2014). Triclosan promotes Staphylococcus aureus nasal colonization. mBio 5:
e01015-13.
17. Dale, R. C. et al. (2004). Encephalitis lethargica syndrome; 20 new cases and evidence of basal ganglia
autoimmunity. Brain 127: 21-33.
18. Mell, L. K., Davis, R. L. e Owens, D. (2005). Association between streptococcal infection and
obsessive-compulsive disorder, Tourette’s syndrome, and tic disorder. Pediatrics 116: 56-60.
19. Fredrich, E. et al. (2013). Daily battle against body odor: towards the activity of the axillary
microbiota. Trends in Microbiology 21: 305-312.
20. Whitlock, D. R. e Feelisch, M. (2009). Soil bacteria, nitrite, and the skin. Em: Rook, G. A. W. org. The
Hygiene Hypothesis and Darwinian Medicine. Birkhäuser Basel, pp. 103-115.
Capítulo 6
1. Zhu, L. et al. (2011). Evidence of cellulose metabolism by the giant panda gut microbiome.
Proceedings of the National Academy of Sciences 108: 17714-17719.
2. De Filippo, C. et al. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study
in children from Europe and rural Africa. Proceedings of the National Academy of Sciences 107: 14691-14696.
3. Ley, R. et al. (2006). Human gut microbes associated with obesity. Nature 444: 1022-1023.
4. Foster, R. e Lunn, J. (2007). 40th Anniversary Briefing Paper: Food availability and our changing diet.
Nutrition Bulletin 32: 187-249.
5. Lissner, L. e Heitmann, B. L. (1995). Dietary fat and obesity: evidence from epidemiology. European
Journal of Clinical Nutrition 49: 79-90.
6. Barclay, A. W. e Brand-Miller, J. (2011). The Australian paradox: A substantial decline in sugars
intake over the same timeframe that overweight and obesity have increased. Nutrients 3: 491-504.
7. Heini, A. F. e Weinsier, R. L. (1997). Divergent trends in obesity and fat intake patterns: The
American paradox. American Journal of Medicine 102: 259-264.
8. David, L. A. et al. (2014). Diet rapidly and reproducibly alters the human gut microbiome. Nature
505: 559-563.
9. Hehemann, J.-H. et al. (2010). Transfer of carbohydrate-active enzymes from marine bacteria to
Japanese gut microbiota. Nature 464: 908-912.
10. Cani, P. D. et al. (2007). Metabolic endotoxaemia initiates obesity and insulin resistance. Diabetes 56:
1761-1772.
11. Neyrinck, A. M. et al. (2011). Prebiotic effects of wheat arabinoxylan related to the increase in
bifidobacteria, Roseburia and Bacteroides/Prevotella in diet-induced obese mice. PLoS ONE 6: e20944.
12. Everard, A. et al. (2013). Cross-talk between Akkermansia muciniphila and intestinal epithelium
controls diet-induced obesity. Proceedings of the National Academy of Sciences 110: 9066-9071.
13. Maslowski, K. M. (2009). Regulation of inflammatory responses by gut microbiota and
chemoattractant receptor GPR43. Nature 461: 1282-1286.
14. Brahe, L. K., Astrup, A. e Larsen, L. H. (2013). Is butyrate the link between diet, intestinal microbiota
and obesity-related metabolic disorders? Obesity Reviews 14: 950-959.
15. Slavin, J. (2005). Dietary fibre and body weight. Nutrition 21: 411-418.
16. Liu, S. (2003). Relation between changes in intakes of dietary fibre and grain products and changes in
weight and development of obesity among middle-aged women. American Journal of Clinical Nutrition 78: 920-927.
17. Wrangham, R. (2010). Catching Fire: How Cooking Made Us Human. Profile Books, Londres.
Capítulo 7
1. Funkhouser, L. J. e Bordenstein, S. R. (2013). Mom knows best: The universality of maternal
microbial transmission. PLoS Biology 11: e10016331.
2. Dominguez-Bello, M.-G. et al. (2011). Development of the human gastrointestinal microbiota and
insights from high-throughput sequencing. Gastroenterology 140: 1713-1719.
3. Se Jin Song, B. S., Dominguez-Bello, M.-G. e Knight, R. (2013). How delivery mode and feeding can
shape the bacterial community in the infant gut. Canadian Medical Association Journal 185: 373-374.
4. Kozhumannil, K. B., Law, M. R. e Virnig, B. A. (2013). Cesarean delivery rates vary tenfold among US
hospitals; reducing variation may address quality and cost issues. Health Affairs 32: 527-535.
5. Gibbons, L. et al. (2010). The global numbers and costs of additionally needed and unnecessary
Caesarean sections performed per year: Overuse as a barrier to universal coverage. World Health Report Background Paper, o N 30.
6. Cho, C. E. e Norman, M. (2013). Cesarean section and development of the immune system in the
offspring. American Journal of Obstetrics & Gynecology 208:249-254.
7. Schieve, L. A. et al. (2014). Population attributable fractions for three perinatal risk factors for autism
spectrum disorders, 2002 and 2008 autism and developmental disabilities monitoring network. Annals of Epidemiology 24: 260-266.
8. MacDorman, M. F. et al. (2006). Infant and neonatal mortality for primary Cesarean and vaginal
births to women with ‘No indicated risk’, United States, 1998-2001 birth cohorts. Birth 33: 175-182.
9. Dominguez-Bello, M.-G. et al. (2010). Delivery mode shapes the acquisition and structure of the
initial microbiota across multiple body habitats in newborns. Proceedings of the National Academy of Sciences 107: 11971-11975.
10. McVeagh, P. e Brand-Miller, J. (1997). Human milk oligosaccharides: Only the breast. Journal of
Paediatrics and Child Health 33: 281-286.
11. Donnet-Hughes, A. (2010). Potential role of the intestinal microbiota of the mother in neonatal
immune education. Proceedings of the Nutrition Society 69: 407-415.
12. Cabrera-Rubio, R. et al. (2012). The human milk microbiome changes over lactation and is shaped by
maternal weight and mode of delivery. American Journal of Clinical Nutrition 96: 544-551.
13. Stevens, E. E., Patrick, T. E. e Pickler, R. (2009). A history of infant feeding. The Journal of Perinatal
Education 18: 32-39.
14. Heikkilä, M. P. e Saris, P. E. J. (2003). Inhibition of Staphylococcus aureus by the commensal bacteria
of human milk. Journal of Applied Microbiology 95: 471-478.
15. Chen, A. e Rogan, W. J. et al. (2004). Breastfeeding and the risk of postneonatal death in the United
States. Pediatrics 113: e435-e439.
16. Ip, S. et al. (2007). Breastfeeding and maternal and infant health outcomes in developed countries.
Evidence Report/Technology Assessment (Relatório Completo) 153: 1-186.
17. Division of Nutrition and Physical Activity: Research to Practice Series No. 4: Does breastfeeding
reduce the risk of pediatric overweight? Atlanta: Centers for Disease Control and Prevention, 2007.
18. Stuebe, A. S. (2009). The risks of not breastfeeding for mothers and infants. Reviews in Obstetrics &
Gynecology 2: 222-231.
19. Azad, M. B. et al. (2013). Gut microbiota of health Canadian infants: profiles by mode of delivery and
infant diet at 4 months. Canadian Medical Association Journal 185: 385-394.
20. Palmer, C. et al. (2007). Development of the human infant intestinal microbiota. PLoS Biology 5:
1556-1573.
21. Yatsunenko, T. et al. (2012). Human gut microbiome viewed across age and geography. Nature 486:
222-228.
22. Lax, S. et al. (2014). Longitudinal analysis of microbial interaction between humans and the indoor
environment. Science 345: 1048-1051.
23. Gajer, P. et al. (2012). Temporal dynamics of the human vaginal microbiota. Science Translational
Medicine 4: 132ra52.
24. Koren, O. et al. (2012). Host remodelling of the gut microbiome and metabolic changes during
pregnancy. Cell 150: 470-480.
25. Claesson, M. J. et al. (2012). Gut microbiota composition correlates with diet and health in the
elderly. Nature 488: 178-184.
Capítulo 8
1. Metchnikoff, E. (1908). The Prolongation of Life: Optimistic Studies. G. P. Putnam’s Sons, Nova York.
2. Bested, A. C., Logan, A. C. e Selhub, E. M. (2013). Intestinal microbiota, probiotics and mental
health: from Metchnikoff to modern advances: Parte I – autointoxication revisited. Gut Pathogens 5: 1-16.
3. Hempel, A. et al. (2012). Probiotics for the prevention and treatment of antibiotic-associated
diarrhea: A systematic review and metaanalysis. Journal of the American Medical Association 307: 1959-1969.
4. AlFaleh, K. et al. (2011). Probiotics for prevention of necrotizing enterocolitis in preterm infants.
Cochrane Database of Systematic Reviews, Edição 3.
5. Ringel, Y. e Ringel-Kulka, T. (2011). The rationale and clinical effectiveness of probiotics in irritable
bowel syndrome. Journal of Clinical Gastroenterology 45(S3): S145-S148.
6. Pelucchi, C. et al. (2012). Probiotics supplementation during pregnancy or infancy for the prevention
of atopic dermatitis: A meta-analysis. Epidemiology 23: 402-414.
7. Calcinaro, F. (2005). Oral probiotic administration induces interleukin-10 production and prevents
spontaneous autoimmune diabetes in the non-obese diabetic mouse. Diabetologia 48: 1565-75.
8. Goodall, J. (1990). The Chimpanzees of Gombe: Patterns of Behavior. Harvard University Press,
Cambridge.
9. Fritz, J. et al. (1992). The relationship between forage material and levels of coprophagy in captive
chimpanzees (Pan troglodytes). Zoo Biology 11: 313-318.
10. Ridaura, V. K. et al. (2013). Gut microbiota from twins discordant for obesity modulate metabolism
in mice. Science 341: 1079.
11. Smits, L. P. et al. (2013). Therapeutic potential of fecal microbiota transplantation. Gastroenterology
145: 946-953.
12. Eiseman, B. et al. (1958). Fecal enema as an adjunct in the treatment of pseudomembranous
enterocolitis. Surgery 44: 854-859.
13. Borody, T. J. et al. (1989). Bowel-flora alteration: a potential cure for inflammatory bowel disease and
irritable bowel syndrome? The Medical Journal of Australia 150: 604.
14. Vrieze, A. et al. (2012). Transfer of intestinal microbiota from lean donors increases insulin
sensitivity in individuals with metabolic syndrome. Gastroenterology 143: 913-916.
15. Borody, T. J. e Khoruts, A. (2012). Fecal microbiota transplantation and emerging applications.
Nature Reviews Gastroenterology and Hepatology 9: 88-96.
16. Delzenne, N. M. et al. (2011). Targeting gut microbiota in obesity: effects of prebiotics and probiotics.
Nature Reviews Endocrinology 7: 639-646.
17. Petrof, E. O. et al. (2013). Stool substitute transplant therapy for the eradication of Clostridium
difficile infection: ‘RePOOPulating’ the gut. Microbiome 1: 3.
18. Yatsunenko, T. et al. (2012). Human gut microbiome viewed across age and geography. Nature 486:
222-228.
Conclusão
1. Markle, J. G. M. et al. (2013). Sex differences in the gut microbiome drive hormone-dependent
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