Condutas Práticas em Infertilidade e Reprodução Assistida: Homem
Conclusão
Um correto diagnóstico das causas de hipogonadismo é fundamental para
uma correta condução clínica e discussão prognóstica da fertilidade. O
hipogonadismo hipogonadotrófico funcional é o que apresenta maiores
chances de sucesso, por não cursar com alterações anatômicas e possuir
testículos funcionantes (apenas não estimulados). O quadro de
hipogonadismo com pior prognóstico é, sem dúvida, o hipergonadotrófico,
porém, como mostrado, os avanços na medicina já permitem uma taxa de
sucesso bastante razoável, mesmo para esses pacientes com função
testicular reduzida.
Referências
Araujo AB, Esche GR, Kupelian V, et al. Prevalence of symptomatic androgen deficiency in men. J
Clin Endocrinol Metab. 2007;92(11):4241–4247. Bouloux PMG, Nieschlag E, Burger HG. Induction of spermatogenesis by recombinant follicle-
stimulating hormone (Puregon) in hypognadotropic azoospermic men who failed to respond to
human chorionic gonadotropin alone. Journal of Andrology. 2003;24(4.).
Corradi PF, Corradi RB, Greene LW. Physiology of the hypothalamic-pituitary-gonadal Axis in the
Male. Urol Clinic North Americ. 2016 http://dx.doi.org/10.1016/j.ucl.2016.01.001.
Coviello AD, Matsunomoto AM, Bremmer WJ, et al. Low Dose Human Chorionic gonadotropin
maintains intratesticular testosterone in normal men with testosterone-induced gonadotropin
supression. The Journal of Clinic Endoc and Metab. 2005;90(5):2595–2602. Depenbusch M, Eckardstein SD, Simoni M, et al. Maintainance of spermatogenesis in
hypogonadotropic hypogonadal men with human chorionic gonadotropin alone. Europ Journal of
Endoc. 2002;147:617–624.
Fraietta R, Zylbersterjn DS, Esteves SC. Hypogonadotropic hypogonadism Revisited. Clinics.
2013;68(S1):81–88.
Herati AS, Cengiz C, Lamb DJ. Essays of serum testosterone. Urol Clin North Am. 2016;43:177–
184.
Hsieh TC, Pastuszak AW, Hwang K, et al. Concomitant intramuscular human chorionic gonadotropin
preserves spermatogenesis in men undergoing testosterone replacement therapy. J Urol.
2013;189(2):647–650.
Liu PY, Turner L, Rushford D, et al. Efficacy and safety of recombinant human follicule stimulating
hormone (Gonal F) with urinary human chorionic gonadotrophin for induction of spermatogenesis
and fertility in gonadotrophin-deficient men. Human Reproduction. 1999;14(6):1540–1545. Matsumoto AM, Snyder PJ, Bhasin S, et al. Stimulation of spermatogenesis with recombinant human
follicle-stimulating hormone (follitropin alfa; Gonal-f): long term treatment in azoospermic men
with hypogonadotropic hypogonadism. Fertil Steril. 2009;92(3.).
Ohlander SJ, Lindgren MC, Lipshultz LI. Testosterone and Male Infertility. Urol Clinic. North Am.
2016; http://dx.doi.org/10.1016/j.ucl.2016.01.006.
Rahnema CD, Lipshultz LI, Crosnoe LE, et al. Anabolic Steroid Induced hypogonadism: diagnosis
and treatment. Fertil Steril. 2014;101(5.).
Ross A, Bhasin S. Hypogonadism. Its Prevalence and Diagnosis. Urol Clin North Am. 2016;43:163–
176.
Sales, Patricia; Halpern, Alfredo. Cercato, Cintia. O Essencial em Endocrinologia. Roca, 2016. Sharlip ID, Jarow JP, Belker AM, et al. Best practice policies for male infertility. Fertil Steril.
2002;77(5.).
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