Condutas Práticas em Infertilidade e Reprodução Assistida: Homem

Conclusão

são experimentais.

• Os homens devem ser advertidos de que pode haver dano genético em

espermatozoides de sêmen coletado após o início da quimioterapia.

• Em crianças, os métodos estabelecidos para a preservação de fertilidade

devem ser utilizados quando apropriados, mediante parecer favorável e

consentimento dos pais ou guardiões.

 

Conclusão

 

Com o aumento da sobrevida dos pacientes com câncer, o esforço em

proporcionar qualidade de vida aos sobreviventes deve ser considerado uma

prioridade para todos os profissionais envolvidos no tratamento multimodal

do câncer.

Acreditamos que a disseminação do conhecimento em oncofertilidade,

bem como a abordagem do tema de forma oficial e sistemática, em

programas de residência médica e formação profissional, contribuirão para

a mudança das práticas vigentes e para que esses pacientes vivam mais e

melhor.

 

Referências

Bandak M, Aksglaede L, Juul A, Rorth M, Daugaard G. The pituitary-Leydig cell axis before and

after orchiectomy in patients with stage I testicular cancer. European journal of cancer.

2011;47(17):2585–2591.

Brydoy M, Fossa SD, Dahl O, Bjoro T. Gonadal dysfunction and fertility problems in cancer

survivors. Acta oncologica. 2007;46(4):480–489. Byrne J, Rasmussen SA, Steinhorn SC, Connelly RR, Myers MH, Lynch CF, et al. Genetic disease in

offspring of long-term survivors of childhood and adolescent cancer. American journal of human

genetics. 1998;62(1):45–52.

Cancer INd. Estimativa 2016 Incidência de Cäncer no Brasil. INCA; 2015.

Chemes HE. Infancy is not a quiescent period of testicular development. International journal of

andrology. 2001;24(1):2–7.

Crowne E, Gleeson H, Benghiat H, Sanghera P, Toogood A. Effect of cancer treatment on

hypothalamic-pituitary function. The lancet Diabetes & endocrinology. 2015;3(7):568–576. Darzy KH, Shalet SM. Hypopituitarism following Radiotherapy Revisited. Endocrine development.

2009;15:1–24.

Djaladat H, Burner E, Parikh PM, Beroukhim Kay D, Hays K. The Association Between Testis

Cancer and Semen Abnormalities Before Orchiectomy: A Systematic Review. Journal of

adolescent and young adult oncology. 2014;3(4):153–159.

Eberhard J, Stahl O, Cwikiel M, Cavallin-Stahl E, Giwercman Y, Salmonson EC, et al. Risk factors

for post-treatment hypogonadism in testicular cancer patients. European journal of endocrinology

/ European Federation of Endocrine Societies. 2008;158(4):561–570.

Fossa SD, Oldenburg J, Dahl AA. Short- and long-term morbidity after treatment for testicular

cancer. BJU international. 2009;104(9 Pt B):1418–1422.

Gerl A, Muhlbayer D, Hansmann G, Mraz W, Hiddemann W. The impact of chemotherapy on

Leydig cell function in long term survivors of germ cell tumors. Cancer. 2001;91(7):1297–1303. Izard MA. Leydig cell function and radiation: a review of the literature. Radiotherapy and oncology :

journal of the European Society for Therapeutic Radiology and Oncology. 1995;34(1):1–8.

Jacobsen KD, Ous S, Waehre H, Trasti H, Stenwig AE, Lien HH, et al. Ejaculation in testicular

cancer patients after post-chemotherapy retroperitoneal lymph node dissection. British journal of

cancer.. 1999;80(1–2):249–255.

Lambertini M, Del Mastro L, Pescio MC, Andersen CY, Azim Jr HA, Peccatori FA, et al. Cancer and

fertility preservation: international recommendations from an expert meeting. BMC medicine.

2016;14:1.

Lee SJ, Schover LR, Partridge AH, Patrizio P, Wallace WH, Hagerty K, et al. American Society of

Clinical Oncology recommendations on fertility preservation in cancer patients. Journal of

clinical oncology : official journal of the American Society of Clinical Oncology.

2006;24(18):2917–2931.

Loren AW, Mangu PB, Beck LN, Brennan L, Magdalinski AJ, Partridge AH, et al. Fertility

preservation for patients with cancer: American Society of Clinical Oncology clinical practice

guideline update. Journal of clinical oncology : official journal of the American Society of

Clinical Oncology. 2013;31(19):2500–2510.

Neal MS, Nagel K, Duckworth J, Bissessar H, Fischer MA, Portwine C, et al. Effectiveness of sperm

banking in adolescents and young adults with cancer: a regional experience. Cancer.

2007;110(5):1125–1129.

Paul C, Robaire B. Ageing of the male germ line. Nature reviews Urology. 2013;10(4):227–234.

Rappaport R, Brauner R, Czernichow P, Thibaud E, Renier D, Zucker JM, et al. Effect of

hypothalamic and pituitary irradiation on pubertal development in children with cranial tumors.

The Journal of clinical endocrinology and metabolism. 1982;54(6):1164–1168. Rives N, Perdrix A, Hennebicq S, Saias-Magnan J, Melin MC, Berthaut I, et al. The semen quality of

1158 men with testicular cancer at the time of cryopreservation: results of the French National

CECOS Network. Journal of andrology. 2012;33(6):1394–1401.

Rowley MJ, Leach DR, Warner GA, Heller CG. Effect of graded doses of ionizing radiation on the

human testis. Radiation research. 1974;59(3):665–678.

Royal College of Physicians TRCoR, Royal College of Obstetricians and Gynaecologists. The effects

of cancer treatment on reproductive. functions: Guidance on management. Report of a Working

Party. 2007.

Schover LR, Brey K, Lichtin A, Lipshultz LI, Jeha S. Oncologists’ attitudes and practices regarding

banking sperm before cancer treatment. Journal of clinical oncology : official journal of the

American Society of Clinical Oncology. 2002;20(7):1890–1897. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA: a cancer journal for clinicians.

2016;66(1):7–30.

Sieniawski M, Reineke T, Nogova L, Josting A, Pfistner B, Diehl V, et al. Fertility in male patients

with advanced Hodgkin lymphoma treated with BEACOPP: a report of the German Hodgkin

Study Group (GHSG). Blood. 2008;111(1):71–76.

Stahl O, Boyd HA, Giwercman A, Lindholm M, Jensen A, Kjaer SK, et al. Risk of birth

abnormalities in the offspring of men with a history of cancer: a cohort study using Danish and

Swedish national registries. Journal of the National Cancer Institute. 2011;103(5):398–406.

Tournaye H, Dohle GR, Barratt CL. Fertility preservation in men with cancer. Lancet.

2014;384(9950):1295–1301.

Wikstrom AM, Dunkel L. Testicular function in Klinefelter syndrome. Hormone research.

2008;69(6):317–326.

 

OceanofPDF.com